Glyceryl trinitrate is also available without a brand name, ie as the generic medicine. Glyceryl trinitrate works by being converted in the body to a chemical called nitric oxide. This chemical is made naturally by the body and has the effect of making the veins and arteries relax and widen dilate. When the blood vessels dilate in this way there is more space inside them and hence less resistance. This makes it easier for the heart to pump blood around the body.
Widening the veins also decreases the volume of blood that returns to the heart with each heartbeat. This makes it easier for the heart to pump that blood out again. As a result of both these actions, the heart does not need as much energy to pump the blood around the body and therefore needs less oxygen. Glyceryl trinitrate also widens the arteries within the heart itself, which increases the blood and oxygen supply to the heart muscle.
The pain of angina is caused by too little oxygen reaching the heart when its workload increases, such as during exercise. Glyceryl trinitrate improves the oxygen supply to the heart, as well as decreasing the amount of oxygen that the heart needs by making it easier for the heart to pump blood around the body.
It can therefore be used to treat angina. GTN sublingual tablets are designed to dissolve quickly under the tongue. This area of the mouth has a large supply of blood vessels that allows the medicine to be rapidly absorbed.
Glyceryl trinitrate taken in this way is used to give rapid relief from the pain of an angina attack. The tablets can also be used to prevent an anticipated attack, for example before exercise or physical effort, emotional stress or exposure to cold.
Glyceryl trinitrate is also available as skin patches and ointment that can be applied regularly each day to help prevent angina attacks. See the factsheets linked at the end of this article for more information. This medicine should not be used if you are allergic to one or any of its ingredients.
Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect. The side effects listed above may not include all of the side effects reported by the medicine's manufacturer.
For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist. If you think you have experienced a side effect from a medicine or vaccine you should check the patient information leaflet. This lists the known side effects and what to do if you get them.
You can also get advice from your doctor, nurse or pharmacist. You can also report side effects yourself using the yellow card website: www. It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine.
Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to make sure that the combination is safe.
The medicines for erectile dysfunction impotence listed below must not be used by people who take glyceryl trinitrate, because the combination can produce a severe drop in blood pressure resulting in dizziness, fainting, or even a heart attack:. If this medicine is taken in combination with other medicines that reduce blood pressure , either as a treatment for high blood pressure antihypertensives , or as a side effect, there may be an enhanced blood pressure lowering effect.
This might make some people feel dizzy. If you do feel dizzy, you should lie down until the symptoms pass. Other medicines that can reduce blood pressure include the following:.
Your glyceryl trinitrate sublingual tablets may be less effective if you are taking medicines that can cause a dry mouth. This is because they are not able to dissolve properly under your tongue. Medicines that can cause a dry mouth include the following:. Take the fewest tablets needed to relieve the pain of your attacks.
If your angina attacks happen more often, last longer, or become more severe at any time during your treatment, call your doctor. Talk to your doctor about how to use nitroglycerin tablets to treat angina attacks. Your doctor will probably tell you to sit down and take one dose of nitroglycerin when an attack begins.
If your symptoms do not improve very much or if they worsen after you take this dose you may be told to call for emergency medical help right away. If your symptoms do not go away completely after you take the first dose, your doctor may tell you to take a second dose after 5 minutes have passed and a third dose 5 minutes after the second dose. Call for emergency medical help right away if your chest pain has not gone away completely 5 minutes after you take the third dose.
Do not chew, crush, or swallow nitroglycerin sublingual tablets. Instead, place the tablet under your tongue or between your cheek and gum and wait for it to dissolve. You may feel burning or tingling in your mouth as the tablet dissolves. This is normal but is not a sign that the tablet is working. Do not be concerned that the tablet is not working if you do not feel the burning or tingling. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Nitroglycerin sublingual tablets are usually taken as needed to treat episodes of angina; do not take them on a regular basis. Nitroglycerin sublingual may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication. Keep this medication in the container it came in, tightly closed after each use, and out of reach of children.
Store it at room temperature and away from excess heat and moisture not in the bathroom. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them.
However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. It is important to keep all medication out of sight and reach of children as many containers such as weekly pill minders and those for eye drops, creams, patches, and inhalers are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location — one that is up and away and out of their sight and reach.
In case of overdose, call the poison control helpline at GTN tablets, which are given under the tongue, are used to treat acute angina pectoris chest pain caused by coronary heart disease. The tablets are used in acute healthcare settings, such as hospitals and ambulances, but can also be used by patients at home. Both Anginine and Lycinate share the same formulation, including the new formulation that is available in a circular tablet the old formulation was a square tablet. To date, the reports of longer than expected time to dissolve and difficulty breaking tablets in half have related only to the new formulation of GTN tablets.
If a GTN tablet does not dissolve properly or quickly enough, the patient may not receive adequate or timely therapy, which could lead to other serious health consequences. The affected products are not being recalled at this time while the TGA continues to investigate the issue.
Please note that there is a spray-based formulation of GTN, marketed as Nitrolingual Pump Spray, and this product is not affected by this issue. The TGA will continue to investigate this issue and will provide further information when it becomes available. If you or someone you care for uses Anginine or Lycinate tablets GTN tablets , please be aware of this issue. Do not stop taking your medicine if you need it.
Continue taking your GTN tablets as directed by your health professional, allowing them to dissolve under the tongue.
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